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However, prolonged or complete PERK inactivation can paradoxically increase genomic instability, thereby predisposing cells to tumorigenesis under certain conditions

Patients carrying specific GLP1R variants may exhibit heightened receptor sensitivity, increasing both the likelihood of GI side effects and the potential for symptom improvement

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Comprehensive policy measures, including take-back programs, better prescription regulations, and the integration of pharmaceutical pollutants into water safety plans, are critical