186 Similarly, lactate from patient-derived GSCs and microglia/macrophages triggers histone Kla, boosting transcriptional upregulation of CD47 in GBM cells, ultimately suppressing phagocytosis and inducing immunosuppressive programs
In contrast, Nrf2 activators, such as sulforaphane, have been found to prevent homocysteine- or hydrogen peroxide-induced cataract formation in human lens epithelial cells by increasing nuclear translocation of Nrf2 and expressions of cellular antioxidants, including catalase, superoxide dismutase, glutathione peroxidase, and glutathione
Overall, these findings demonstrated that MitoQ might be promising tools for pathological changes of mitochondrial oxidative damage associated with age-related diseases
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