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Most trials enrolled participants with overweight or obesity, so extrapolating results to normal-weight populations requires careful interpretation

HoJLyassALeeDVasanRKannelWLarsonMet alPredictors of new-onset heart failure: differences in preserved versus reduced ejection fraction

Because it floods the receptor with a non-pulsatile signal, the body's own GH feedback loops are suppressed during administration a key reason researchers distinguish it from GHRH/GHRP stacks