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Severe caloric restriction can also negatively affect metabolism and lean muscle mass

276,421 Taken together, these observations identify the important role of ERAD, through its diverse components exemplified by HRD1 here, in the control of metabolic networks, from lipid metabolism to insulin tolerance, which are implicated in a number of physiological processes, from aging to obesity

Starting Mounjaro can bring up a lot of questions, especially around side effects