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A definitive cause for virus reactivation has not been identified, but risk factors include: older age HIV/AIDS cancer and cancer treatment having a suppressed immune system family history biological female sex stress physical trauma coexisting medical conditions like diabetes, rheumatoid arthritis, inflammatory bowel disease, and renal disease excess sun exposure About Disseminated shingles affects about 15% to 30% of people with compromised immune systems, and about 2% of all people

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