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It is a first-in-class, multitarget inhibitor of the PI3K/AKT/mTOR pathway, filed under priority review for HR-positive, HER2-negative, PIK3CA wild-type advanced breast cancer in patients who have progressed after CDK4/6 inhibitor and aromatase inhibitor therapy

Long SP, Ainsworth EA, Leakey ADB, Nsbsrger J, Ort DR (2006) Food for thought: Lower-than-expected crop yield stimulation with rising CO concentrations