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Utilizing a variety of animal models of TMJ OA caused by unilateral anterior crossbite (UAC), occlusion disorder (OD), monosodium iodoacetate (MIA), and IL-1, the study shows that ferroptosis, which is typified by elevated p53 and ACSL4 and decreased GPX4, is a major contributor to TMJ OA

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Glutathione levels can be reduced by a number of factors including: Poor nutrition Genetically modified foods Environmental toxins Overuse of antibiotics Infections Injuries Stress Aging Glutathione is pivotal to our health because it plays several vital roles in the body