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After injection, withdraw the needle at the same angle it was inserted, release the skin fold (if used), and apply gentle pressure with a clean cotton ball or gauze if needed

Key open questions include how consistently this mechanism operates across different patients and different GLP-1 medications, whether the effect is dose-dependent or reversible after stopping treatment, and how significantly this cellular mechanism contributes to visible skin laxity relative to the simpler mechanical explanation of volume loss and skin's retraction capacity

The overall incidence of adverse events for the 8-trial, short-term, placebo-controlled pool in adult patients treated with dapagliflozin 10 mg and metformin HCl was 60.3% compared to 58.2% for the placebo and metformin HCl group

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