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A 2020 review in Diabetes Care noted that "the hypoglycaemic effect of IGF-1 has been exploited therapeutically in rare forms of insulin-receptor-defect syndromes, but the risk-benefit calculation differs fundamentally from use in euglycaemic individuals" [20]

Branching chain amino acids (leucine, isoleucine, valine) particularly important for protein synthesis signaling

sleep effects have not been studied in controlled trials

A number of clinical studies established that GHK-CU stimulates the synthesis of collagen, the production of selected glycosaminoglycans (like hyaluronic acid), and modulates matrix metalloproteinases (MMPs)