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The medication has accumulated over 14 years of clinical trial data and approximately 7 years of real-world post-marketing experience

On day 1, each mouse was administered an IP dose of either vehicle or GIPR-Ab/GLP-1 at a dosage of 10 nmol kg 1

Side effects and tolerability Both medications share similar gastrointestinal side effects, which are typical for all GLP-1 receptor agonists

The STEP TEENS Trial: Closest Available Pediatric Evidence The nearest evidence comes from STEP TEENS, a 68-week, double-blind, placebo-controlled trial that enrolled 201 adolescents aged 12 to 17 with obesity (or overweight with at least one comorbidity) [4]