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Bottom line: At this point, there is no clear evidence that GLP-1 agonists cause depression or suicidal behavior in the average patient, but there are signals that merit caution

Never double up on doses to make up for a missed injection

Whilst physiological levels of estradiol are inversely associated with binge eating, it appears that abnormally high levels of estradiol are actually positively associated with binge eating and emotional eating (54, 55, 59, 60)

Why GLP-1 Medications Cause Side Effects GLP-1 medications work by slowing gastric emptying, reducing appetite signaling, and improving insulin regulation