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Recorded levels of MTX after 24 h of administration showed that in CARN-depleted rats, the observed higher MTX level could be due to lowered excretion, as CARN has been proven to impact energy metabolism in renal tubules [79]

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The FOLR1 gene represents one member of a family of folate receptor genes that are clustered at the 11q13.4 locus

At this point, the compounds are generally non-toxic and excreted from the body through bile or urine