Secondary BAs play a role in the modulation of immune system activity through BAs receptors, such as Takeda G-protein-coupled BAs receptor-1 (TGR5), farnesoid X receptor (FXR), pregnane X receptor (PXR), retinoid-related orphan receptor-t (RORyt), and Vitamin D receptor (VDR) [25]
Effectiveness of inositol, metformin and their combination in women with PCOS undergoing assisted reproduction: systematic review and meta-analysis
Another advance was the cloning of the intercellular proteins such as zonulins, claudins, occludins, tricellulins, and the many other protein components that comprise the tight junctions, facilitating the understanding of their contributions toward junctional structure and paracellular permeability [33, 38]
The BBB is a highly selective semipermeable membrane barrier that exists between the brain and blood and maintains homeostasis in the brains internal environment (Neuwelt et al., 2011)