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The full clinical study protocol and prespecified statistical analysis plan are available in the Supplementary Information (Supplementary Notes 2 and 3)

Niacinamide is one of two major forms of vitamin B3, the other being niacin (nicotinic acid)

doi: 10.1172/JCI128212 108 ZhangXColemanIMBrownLGTrueLDKollathLLucasJMet al

A randomized controlled trial in 167 older adults (50 years) found two-year supplementation with vitamin B 12 (10 g/day), along with folic acid (200 g/day), vitamin B6 (10 mg/day), riboflavin (5 mg/day), and vitamin D (10 g/day), had no effect on bone mineral density (total hip, femoral neck, or lumbar spine) compared to the control group only receiving vitamin D (10 g/day ) (116)