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Modulates gastric emptying and nutrient flux: Amylin receptor activation influences gastrointestinal motility by slowing gastric emptying

In islet alpha cells, GLP-1(936) led to inhibition of Ca 2+ entry via voltage-gated Ca 2+ channels sensitive to -agatoxin, with consequential pertussis-toxin-sensitive depletion of the docked pool of secretory granules, effects that were prevented by the glucagon receptor antagonists REMD2.59 and L-168049

Supports nerve health and reduces symptoms like tingling or numbness

Some studies suggest Tirzepatide may produce greater average weight loss, although results vary from person to person