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For LCMS analysis, metabolite extracts were analysed by high-resolution mass spectrometry with an Orbitrap Exploris 240 (Thermo) coupled to a Vanquish Flex liquid chromatography system (Thermo)
There, it plays a major role in detoxification pathways, which help the body process and eliminate toxins, drugs, and other harmful substances
We further point out that there are there few patients in this study ( n = 7) who were on insulin, hence it is unclear if the observations described here extend to those in whom insulin insufficiency is severe
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