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DPP-4 is a type II transmembrane glycoprotein (766 residues), involved in numerous signaling pathways (e.g., cellcell interaction and activation of transduction pathways of intracellular signals), although, under some stimuli (e.g., tumor necrosis factor (TNF) and chronic low-grade inflammation), this molecule can be released in the blood as a soluble form (sDPP-4, a protein of 727 amino acids) [45,46]

Safety Experiments in animal models have proven that FOXO4-DRI is capable of inducing senescent cell clearing

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