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Supplementary material The Supplementary material for this article can be found online at: Abbreviations FDR, False discovery rate

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In this regard, it has been shown that tamoxifen, a type of selective estrogen receptor modulator (SERM) that acts as a competitive antagonist or as a partial agonist depending on the cell type, favors the repair of demyelinated lesions in the CNS by increasing the mRNA levels of myelin basic protein (MBP) and 2, 3-Cyclic nucleotide 3-phosphodiesterase (CNP), two genes highly expressed during oligodendroglial differentiation (Table 1)