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[2] In 2002, after he had left for Harvard, he clashed with Guarente at a scientific meeting at Cold Spring Harbor Laboratory, challenging Guarente's description of how sir2 might be involved in aging

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And there can be very real negative side effectsnausea, fatigue, dizziness, muscle and hair lossand some people have even reported increased depression and suicidal ideation, although a large-scale meta study seemed to show no direct link to the medication itself

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