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2.5 Quality assessment and risk of bias In line with PRISMA guidelines, the assessment of methodological quality was conducted to evaluate the strength of evidence, recognising that methodological limitations may introduce bias

These can include nausea, abdominal cramps, and allergic reactions

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Data from the EFFISAYIL program show spesolimab provides: Sustained reduction in flare frequency over 3 years ~75% of patients remaining flare-free Stable safety profile with no new signals Given the severity and unpredictability of GPP, these findings reinforce the value of targeted IL-36 inhibition for durable disease suppression