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MC4R agonism has been shown to induce synaptic changes by increasing AMPA receptors, alterations in dendritic spine densities and increasing sensitivity to glutamate

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March 14 Product: Madrigals Rezdiffra Indication: MASH In one of the years most highly anticipated FDA decisions, Madrigal Pharmaceuticals won approval Thursday for resmetiromhenceforth to be known as Rezdiffraas the first-ever treatment for metabolic dysfunction-associated steatohepatitis (MASH), formerly noncirrhotic non-alcoholic steatohepatitis (NASH)