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Most advanced is tirzepatide, a GIP-GLP-1 co-agonist, which was recently approved for diabetes therapy in the US

Furthermore, a third melatonin-binding site (MT3) has been characterized and identified as the cytosolic enzyme quinone reductase 2 (QR2), a known detoxifying enzyme that reduces menadione and other quinones 26,27

Any changes to GLP-1 dosing, including maintenance or micro-dosing, should be done under medical supervision to ensure safety, effectiveness, and personalized care.

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