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Neves JS, Borges-Canha M, Vasques-Nvoa F, Green JB, Leiter LA, Granger CB, et al

The question was whether transitioning them to orforglipron would preserve those results or whether they would regain the weight

NICE guidance (NG28) supports the use of incretin-based therapies in type 2 diabetes management when metformin and other oral agents prove insufficient

Specifically, GLP-1RAs exert protective effects on exercise-induced cardiomyopathy via increasing autophagy, reducing inflammation-related proteins and ROS generation via restoring the expression of catalase and manganese superoxide dismutase (MnSOD) [81]