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113,114,115,116,117 The Aldehyde dehydrogenase 1 isoform A3 (ALDH1A3), normally not expressed in mature islets, is activated in diabetic patients, which damages characterization of cells, leads to dedifferentiation and impairs secretory function

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A broader Euro-DEN Plus study of 43,633 emergency presentations involving CNS depressant drugs found that ethanol co-ingestion increased adverse effects and treatment needs across the group, with GHB and GBL cases showing a particularly strong impact

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