(iii) coordinating the protein and nucleotide synthesis (as an amino acid exchanger, for the import of serine) of murine breast tumor cells, lung tumor cells, hepatocellular carcinoma cells and liposarcoma, promoting the resistance to glutamine deprivation (in breast tumor cells and liposarcoma) and mTOR activation [227,228,229]
Nutrient deprivation, particularly cystine and amino acid starvation triggers CHAC1 expression to help the cell adapt (Chen M.-S
A highly reducing environment is maintained in subcellular compartments, e.g., the cytosol, nucleus, mitochondrial matrix, and peroxisome, to facilitate proper protein folding and activity
Glutathione is undoubtedly part of a vast complex of cellular machinery processes