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We also explained the details of the gene protein product (GP)s quantification in our previous publication 15

JAMA Surg 159:1118 Guidozzi N, Wiggins T, Ahmed AR, Hanna GB, Markar SR (2019) Laparoscopic magnetic sphincter augmentation versus fundoplication for gastroesophageal reflux disease: systematic review and pooled analysis

CYP450 2E1 and 3A4 convert approximately 5% paracetamol to a highly reactive intermediary metabolite N-acetyl-p-benzoquinone imine (NAPQI)

Mechanisms include increased growth factor expression (VEGF, FGF, EGF), enhanced fibroblast migration and proliferation, improved collagen organization, and accelerated revascularization