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TABLE 3 Summary of renoprotective approaches targeting autophagy/mitophagy in CP-induced AKI

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A primate study by Goncharova, Khavinson and colleagues reported that epitalon significantly stimulated evening melatonin synthesis in senescent monkeys and normalised cortisol circadian rhythm both of which are essential for restorative sleep

Gastrointestinal Toxicities Gastrointestinal toxicities are the second most common irAEs observed with ICI therapy, and they range from mild diarrhea to severe colitis and intestinal perforation, which can lead to death (Cramer & Bresalier, 2017