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Grosser et al, 2023)

The agency applied the four-factor framework set out in 21 CFR 216.23(c), covering physical and chemical characterisation, safety, evidence of effectiveness, and historical use

In astudyinvolving rats, BPC-157 was administered in doses of 0, 0.1, 0.25, and 0.5 micrograms/mL over 24 hours. Results showed that the 0.5 microgram/mL dose significantly increased growth hormone expression from day 1 to day 3, while lower doses also had similar effects. The study concluded that BPC-157 supplementation led to increased up-regulation of growth hormone in a dose and time-dependent manner

Figure 7 Figure 8 Concerning the epigenetic modification marker, the mRNA level of Dnmt3 gene in the F1 generation was reduced in the low-dose group