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Exogenous administration of IGF-I is able to induce muscle hypertrophy 33,78,85,86 , and high levels of IGF-I can enhance satellite cell division, increasing the pool of cells available for repair and growth 67

MAPK pathway, which is a non-classical pathway, plays a crucial role in cell growth, proliferation, differentiation and apoptosis

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Conclusively, ETCO 2 demonstrated a significant positive correlation with altitude and a moderate positive correlation with AMS incidence, and was found to be a superior predictor of AMS compared to mere altitude measurements alone