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And GLP-1R knockdown markedly abolished the effect of liraglutde to modulate the ratio of p-Akt/t-Akt after liraglutide treatment, when compared with both the control and negative control siRNA group (Supplementary Figure S1a and c)

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The GBA gene is located in the lysosome and codes for lysosomal enzymes, thus leading to problems in protein degeneration and increasing exosomal release of -Syn (Booth et al., Figure 1 After all, it can be concluded that there is a great possibility in PD patients to observe a non-functionality in glial cells

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