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Background HO level was 143,596 RLU

Parkinsons disease Parkinsons disease (PD) is a long-term neurodegenerative disorder that affects the motor system, characterized primarily by the death of dopaminergic neurons in the substantia nigra and the presence of intracellular aggregates of misfolded -synucleine (Lewy bodies) in the surviving neurons 54,55

Although Otto Warburgs theory of aerobic glycolysis laid the foundation for tumor metabolism research, this metabolic pathway has not been successfully exploited in the clinic, largely due to the adverse side effects and limited efficacy of 2-deoxyglucose, which inhibits glycolysis

The impacts of BPA were more prominent when exposure occurred at 72 hpf compared to 7 dpf, suggesting the developing retina is more susceptible to long-term dysregulation of E 2 signaling by BPA