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Despite the discovery of the mAR in various cell types, including macrophages and T lymphocytes [109, 110], prostate [111] as well as breast [112] cancer cells, the identity of such receptor remains still debated

Metabolic/bariatric surgery in the past 5 years was found in 5.4% of patients

Since 2022, a surge in demand for some of these medicines, coupled with other issues such as manufacturing capacity constraints, has led to shortages across the EU

In Canada, GLP-1 medications are already a significant driver of drug plan spending an Alberta Blue Cross report that reviewed new drug and supplemental submissions made to Health Canada in 2025 named such treatments as a major cost of employer-sponsored drug plans, particularly as the drugs are approved for treatment of more conditions