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Another approach to modulate NNMT involves bisubstrate inhibitors, which are designed to resemble both the substrate (NAM) and the cofactor (SAM)
Kim KS, Park JS, Choi HJ
Its designed to mimic three key metabolic hormones : GLP-1 (glucagon-like peptide-1) GIP (glucose-dependent insulinotropic polypeptide) Glucagon This makes it a triple agonist , meaning it activates three different hormone receptors that are involved in metabolism, appetite regulation, and fat burning
This is typical for many injectable medications, as a clear solution makes it easier to check for any particles or issues before injecting
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