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However, a few commenters expressed that the LithoVue TM Elite Ureteroscope should not receive approval for transitional pass-through payments, because the applicant did not provide sufficiently robust, peer-reviewed clinical evidence that demonstrates a clear benefit to patient outcomes over existing ureteroscopes

Hutton DW, Stein JD, Glassman AR, Bressler NM, Jampol LM, Sun JK, et al

The latter protocol also showed no change in maximal isometric, concentric and eccentric force using this dosing strategy

The nuclear isoform, in particular, is involved in the process of the chromatin condensation, which occurs in the final steps of spermatogenesis and requires the replacement of the majority of histones, with transition proteins and protamines, essential for the stabilization of DNA and condensation of spermatocytes