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A study found that the NRF2-KEAP1 complex keeps shuttling constantly between the cytoplasm and the nucleus, and in the nucleus, the nuclear protein prothymosin competes for NRF2 binding to KEAP1 and enables the liberated NRF2 to activate NRF2 target genes [15]

And for those interested in NAD+ for skin benefits, NRs ability to raise NAD+ levels may also support skin health at the cellular level.

This protein can bind zeaxanthin and meso-zeaxanthine in the retina, suggesting that it can modulate antioxidant levels in the human eye [91,92]

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