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It was demonstrated that melatonin treatment significantly reduced the relative abundance of Clostridium perfringens, markedly increased the relative abundance of Lactobacillus, and dramatically improved function after SCI ( Neuroprotective function of melatonin Melatonin was effective in ameliorating neuronal apoptosis and consequently protecting neurons after SCI ( via Wnt/- Catenin signaling pathway to regulate autophagy and apoptosis (Figure 3)

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The review described the interplay of these systems as constituting a coordinated, multi-layered defence network centred on GSH availability

Kumar D, Kukreti G, Rana R, Chaurasia H, Sharma A, Sharma N (2023) Poly(lactic-co-glycolic) Acid (PLGA) nanoparticles and transdermal drug delivery: an overview