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The percentage of weight loss in the 5mg cagrilintide group was significantly higher than that in the liraglutide group (10.8% vs

Additional safety considerations include: Diabetic retinopathy complications : People with pre-existing diabetic retinopathy using semaglutide should have appropriate ophthalmological monitoring, as rapid improvement in blood glucose control may be associated with temporary worsening of retinopathy Dehydration and acute kidney injury : Significant gastrointestinal side effects may lead to dehydration

ACS Appl Mater Interfaces 8(39):2568025690

Peer review Peer review information Nature Metabolism thanks the anonymous reviewers for their contribution to the peer review of this work