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Furthermore, mitochondrial dysfunction is linked to other processes implicated in the pathophysiology of both major depressive disorders and Alzheimers disease, such as oxidative stress, inflammation, and insulin resistance

Similarly, in intestinal epithelial cells from IBD patients, excessive ER stress induces increased trypsin-like activity, which activates protease-activated receptors 2 and 4, disrupting barrier function and increasing intestinal permeability [89]