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A normal response to the stimulus was first determined in the unoperated left hind limb and was defined as an immediate withdrawal of the limb with or without a vocalization

Therefore, an innovative dosage form needed to be tested

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Combined triad-GSH metabolism model simulations: quinone metabolism and ROS production Following the parameterisation and sensitivity analysis, the triad model was expanded to include GS-H 2 Q adduct formation (quinone removal) and was combined with the glutathione metabolism model constructed by Reed et al