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Current strategies attempting to improve GSH bioavailability are based on the prodrug approach, using GSH prodrugs or derivatives, like N-acetylcysteine (NAC), a well absorbed precursor of cysteine, the main limiting factor in GSH synthesis [2,7-8]

Copper serves as a key enzymatic cofactor for pathways involved in collagen and elastin maturation (cross-linking) , antioxidant defense , and broader tissue remodeling