semaglutide causing constipation GLP-1 Gut Side Effects: Bloating & Tips how to deal with constipation

You may worry about the implications of prolonged drug use and seek to find a more sustainable solution

As a result, many doctors have begun prescribing it not only for diabetes but also for long-term weight management

A patient-centered switching strategy (e.g., from dulaglutide to semaglutide or tirzepatide ) and behavioral integration (nutrition, activity, sleep, stress) were emphasized to support durable success

Mechanistically, Sodium-glucose cotransporter 2 (SGLT2) inhibitors restore tubuloglomerular feedback, reduce intraglomerular pressure, improve proximal tubular metabolic stress, and are associated with indirect inhibition of pro-inflammatory/pro-fibrotic signaling (such as alleviating interstitial inflammation and oxidative stress), thereby slowing structural progression (Stevens et al., 2024