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Instead, the drug failed to show non-inferiority against Lillys Zepbound in the REDEFINE 4 Phase 3 head-to-head trial reported in February 2026, delivering 23.0% weight loss versus 25.5% for tirzepatide, triggering another wave of investor disappointment

Several leading products have received label expansions after demonstrating significant reduction in major adverse cardiovascular events in clinical trials

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These studies are internally coherent but contribute primarily supportive rather than confirmatory evidence