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PINK1: PTEN-induced kinase 1

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GLP-1 receptor agonist injections like Semaglutide and Tirzepatide are offering life-changing weight loss for many women struggling with PCOS-related weight gain

Pharmacologic activation of this pathway by metformin amplifies Treg populations (104), while glycolysis inhibition with 2-deoxyglucose (2-DG) shifts metabolism toward FAO, thereby promoting a phenotypic switch from Th17 to Treg cells ( FAO-driven OXPHOS is necessary for Treg cells to continue their suppressive role (105)