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Also, a proteomic study on primary AML cells derived from patients in their first relapse shows enrichment of mitochondrial ribosomal proteins (Mitochondrial Ribosomal Protein L21 -MRPL21-, Mitochondrial Ribosomal Protein S33 -MRPS3-), and CTE proteins: Translocase of Inner Mitochondrial Membrane Domain Containing 1 (TIMMDC1), a chaperone protein involved in the assembly of Complex I, and Mitochondrial Import Inner Membrane Translocase subunit (Tim8B TIMM8B), a chaperone that participates in the import and insertion of some transmembrane proteins in the inner mitochondrial membrane (Vellinga et al., 2015)

8 weeks 2 vials 8 full weekly maintenance doses

This drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function

Y., Kuo, Y