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Enrichment analysis also identified pathways less well-recognized as IGF-related, including immune regulator-associated pathways, almost all with negative enrichment scores suggesting pathway inactivation (Supplementary Tables S8-10)

Phytates & phosphorus binders (IP6, rice bran) to prevent vascular calcification

In melanoma, downregulation of IGF-1 reduces the dry character of melanoma initiating cells, including the expression of dry markers (SOX2, Oct-3/4, CD24 and CD133) and functional properties (melanosphere formation, aldehyde dehydrogenase activity and side population) and eventually inhibiting the proliferation and metastasis of tumor cells (26)

Impurities can act as confounding variables, producing false-positive or false-negative results