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Third, the management goals may differ by age: in children and adolescents with early-onset, severe disease, halting relentless weight gain and improving metabolic and behavioral comorbidities may constitute primary success, whereas in adults, reversing weight regain and ameliorating cardiometabolic risk factors are central

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In order to have a statistically significant way to measure the success of the program, we use a standard set of criteria, including BMI levels

GSH behaves as redox sensor at the DNA synthesis onset by maintaining nuclear architecture providing the appropriate redox environment for DNA replication and safeguarding DNA integrity (72) and is a key regulator of epigenetic events critical in cell proliferation regulation and cellular resistance to apoptosis (73)