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Patients were excluded if there was a history of bariatric surgery or use of a branded AOM that was approved by the FDA for chronic use (phentermine/topiramate [Qsymia], bupropion/naltrexone [Contrave], liraglutide [Saxenda] or orlistat [Xenical]) or other GLP1 RAs (liraglutide [Victoza], dulaglutide [Trulicity], exenatide [Byetta, Bydureon, Bydureon BCise] or lixisenatide [Adlyxin]) during the baseline period

MOTS-C's effects are systemic and long-lasting

At steady state, whether the most recent dose absorbed in 4 hours or 8 hours makes virtually no difference to your overall blood levels

You will likely hear a clicking sound or see the dose counter return to zero