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Uchida H, Nakajima Y, Ohtake K, et al

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In an in vivo study, administration of MOTS-c intraperitoneally to de-ovalized osteoporotic mice once daily for 12 weeks at a dose of 5 mg/kg, lead to an increased positive trend in several bone formation parameters, such as bone mineral density, bone volume/tissue volume, bone trabecule number, and bone trabecule thickness, indicating that the MOTS-c intervention effectively reduced bone loss