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Then using a H 2 O 2 -induced senescent TM3 Leydig cell model, we found that FOXO4 maintains the viability of senescent Leydig cells and that the FOXO4 blocker FOXO4-DRI induces apoptosis in these senescent cells

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2.14 Animal model and experimental protocol 2.14.1 Establishment of ischemia-reperfusion mouse model and drug administration protocol Mice (C57BL/6 strain) were housed under controlled environmental conditions with a 12-hour light/dark cycle and ad libitum access to standard rodent chow and water

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