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The evaluation of patient preferences regarding oral versus injectable therapies could also be considered, as oral therapies can offer quality-of-life benefits through simplified administration (albeit with oral semaglutide requiring administration in a fasting state with 120 ml of water, followed by a post-dose fasting period of at least 30 min for optimum efficacy) and through shorter waiting times to initiation, with injectable antidiabetic therapies often associated with delays before patient training can be delivered through the NHS in the UK [19]

Patients with idiosyncratic DILI with severe hypersensitivity or DRESS syndrome, may also benefit from corticosteroids (generally 1mg/kg of methylprednisolone)

Interestingly, patients receiving GLP-1 receptor analogs and producing anti-drug antibodies appear to have more injection site reactions because patients who do not produce antibodies experience comparable frequency and forms of adverse effects to those experienced

To mitigate this: eat smaller, more frequent meals (56 times daily) rather than three large meals